SCIENTIFIC PROGRAM

SCIENTIFIC PROGRAM

SUNDAY, May 26, 2019
16:00 – 17:30 h COURSE: Venomous animals: management (practical and theoretical), identification, accidents and poisons for the prospection of biopharmaceuticals
Rui Seabra Ferreira Jr.(CEVAP-UNESP, Botucatu Brazil)
19:30 h OPENING CEREMONY – SBTx Board of Directors
19:45 h OPENING CONFERENCE
Bryan G. Fry (University of Queensland, Queensland, Australia)
Endless forms most deadly: the dynamic diversification of reptile venoms
Chair: Yara Cury, Instituto Butantan, São Paulo, Brazil
20:30 h SBTX’S 30TH ANNIVERSARY CELEBRATION (exhibition and lecture) AND WELCOME RECEPTION
MONDAY, May 27, 2019
7:30 h – 8:15 h COURSE
Strategies for valuing nature assets: the essential steps between the experimental
findings and the drawing of business models
Ricardo A. Remer (Remer, Villaça & Nogueira, São Paulo, Brazil)
08:30 – 10:00 h SESSION I
Omics and Evolution
Chairs: Consuelo L. Fortes-Dias, Fundação Ezequiel Dias, Minas Gerais, Brazil and Inácio L.M. Junqueira de Azevedo, Instituto Butantan, São Paulo, Brazil
08:30 h Beyond snake venom gland: evidences of other oral glands as alternative sources of
toxins and auxiliary molecules
Inácio L. M. Junqueira De Azevedo (Instituto Butantan, São Paulo, Brazil)
08:55 h Structural analysis of the natural inhibitor of BJ46a venom metalloendopeptidases and its target toxin, jararagine, based on XL-MS and HDX-MS
Richard Valente (Fundação Oswaldo Cruz, Rio de Janeiro, Brazil)
09:20 h Could venom variation be the main mechanism shaping snake distribution on Brazilian
islands?
Felipe Grazziotin (Instituto Butantan, São Paulo, Brazil)
09:45 h
A comprehensive portrait of Ectatomma opaciventre ant venom: transcriptome analysis and biological characterization
Lucas Ian Veloso Correia (Universidade Federal de Uberlândia, Uberlândia/MG, Brazil)
10:00 h – 10:30 h
PLENARY LECTURE I

Integrative approaches in the search of marine natural products with anticancer properties
Leticia Costa-Lotufo (USP, São Paulo, Brazil)
Chair: Benedito Barraviera, CEVAP, Botucatu, Brazil

10:30 – 11:00 h COFFEE BREAK

SBTx jovem activity “Guess the Quantity”

11:00 – 11:35 h PLENARY LECTURE II
Integrated studies to understand snake venom proteinase effects upon cells and tissues
Solange Serrano (Instituto Butantan, São Paulo, Brazil)
Chair: Marcos Roberto de Mattos Fontes, UNESP, Botucatu, Brazil
11:35 – 13:15 h SESSION II
Toxins Effects and Mechanisms
Chairs: Mario Sergio Palma, UNESP, Rio Claro, Brazil and Denise V. Tambourgi, Instituto Butantan, São Paulo, Brazil
11:35 h The complex array of activities of Bothrops sp. snake venom proteins on blood platelets: in vitro, ex vivo and in vivo studies
Marcelo Santoro (Instituto Butantan, São Paulo, Brazil)
12:00 h Crotalphine and analgesia: Epigenetic mechanisms
Flavia Santa Cecilia (Instituto Butantan, Brazil)
12:20 h Differential anti-inflammatory and anticoagulant efficacy of the plant inhibitor EcTI contributes to impair the pathophysiology aspects of thrombosis
Maria Luiza Vilela Oliva (UNIFESP, São Paulo, Brazil)
12:40 h
A snake venom metalloproteinase induces inflammatory response in preadipocytes. New insights into the protagonists of inflammatory diseases
Priscila Signor Motta (Instituto Butantan, São Paulo/SP, Brazil)
12:55 h Intradermal application of jararhagin-C, a disintegrin-like cys-rich protein from Bothrops jararaca venom, accelerated wound healing, improved angiogenesis and matrix deposition during skin repair
Bruno Antonio Ferreira (UFU, Uberlândia/MG, Brazil)
13:10 h LUNCH
14:45 – 15:25 h PLENARY LECTURE III
Toxins and Drug Development
Mande Holford (Hunter College and CUNY Graduate Center, New York, USA)
Chair: Ana Marisa Chudzinski-Tavassi, Instituto Butantan, São Paulo, Brazil
15:25 – 17:30 h SESSION III Toxins and Drug Development
Chairs: Gisele Picolo, Instituto Butantan, São Paulo, Brazil and Jonas Perales, FIOCRUZ, Rio de Janeiro, Brazil
15:25 h Animal venoms as tools for the discovery of new molecular targets: Strategies developed by CENTD
Ana Marisa Chudzinski-Tavassi (Instituto Butantan, São Paulo, Brazil)
15:50 h A synthetic peptide derived from Lycosa erythrognatha venom, as a potential antibiotic against some resistant strains of bacteria, in planktonic and biofilm conditions
Maria Elena de Lima Perez Garcia (Santa Casa BH Ensino e Pesquisa, Minas Gerais, Brazil)
16:15 h Exploring the arsenal of peptide toxins from the venoms of social wasps for the rational development of novel therapeutic drugs
Mario Sergio Palma (UNESP, Rio Claro, Brazil)
16:40 h Natural inhibitors of snake venom toxins: a promising source of therapeutic peptides for toxin-centric next-generation antivenoms
Ana Gisele C. Neves-Ferreira (FIOCRUZ, Rio de Janeiro, Brazil)
17:00 h Effect of leucine to phenylalanine substitution on antibacterial and antitumoral properties of biomimetic peptides derived from venom toxins
José Rafael de Almeida (Universidad Regional Amazónica IKIAM, Tena, Ecuador)
17:15 h Snake venom activities as a tool to develop new metalloproteinase inhibitors from synthetic derivatives of lapachol
Paulo A. Melo (Universidade federal do Rio de Janeiro, Rio de Janeiro, Brazil)
17:30 h- 18:00 h COFFEE BREAK
17:30 – 19:00 h POSTER SESSION I
19:00 – 21:00 h EXTRAORDINARY ASSEMBLY OF THE SBTX
TUESDAY, May 28, 2019
7:30 h – 8:15 h COURSE
Strategies for valuing nature assets: the essential steps between the experimental findings and the drawing of business models
Ricardo A. Remer (Remer, Villaça & Nogueira, São Paulo, Brazil)
08:30 – 10:00 h Discussion Panel I
Antivenoms
Chairs: Denise V. Tambourgi, Instituto Butantan, São Paulo, Brazil and Dimas T. Covas, Instituto Butantan, São Paulo, Brazil
08:30 h An overview of the production of antivenoms in the world
Denise V. Tambourgi (Instituto Butantan, São Paulo, Brazil)
08:45 h Procedures for registration of hyperimmune sera in Brazil
Neemias Silva de Andrade (GPBIO,ANVISA, Brasília, Brazil)
09:00 h Prospecting, development, optimization and clinical trial of new antiapilic antivenom
Rui Seabra Ferreira Junior (CEVAP, Botucatu, Brazil)
09:15 h Strategies to improve the availability of antivenom for treating snakebite envenoming in Africa
Jose Maria Gutierrez (Universidade da Costa Rica, San Jose, Costa Rica)
09:30 h Program for attention to accidents by venomous animals in the State of São Paulo.
Dimas Covas (Director, Instituto Butantan, Brazil)
09:45 h Discussion
10:00 – 10:20 h COFFEE BREAK
10:20 – 11:00 h PLENARY LECTURE IV
Emerging therapeutic alternatives for snakebite envenoming
Jose Maria Gutierrez (Universidade da Costa Rica, San Jose, Costa Rica)
Chair: Yara Cury, Instituto Butantan, São Paulo, Brazil
11:00 – 12:20 h SESSION IV Clinical Practices in Envenomations
Chairs: Gisele Pidde, Instituto Butantan, São Paulo, Brazil and Vidal Haddad Junior, UNESP, Botucatu, Brazil
11:00 h Accidents by aquatic animals: clinical and experimental advances over the last 20 years, with emphasis on sea and river stingrays
Vidal Haddad Junior (UNESP, Botucatu, Brazil)
11: 25 h Infrared thermography to diagnose and manage venomous animal bites and sting
Carlos Medeiros (Instituto Butantan, São Paulo, Brazil)
12:05 h Potential utilization of a polysaccharide of the marine algae Gayralia oxysperma, as an antivenom for viperidae snakebites
Ana Cláudia Rodrigues Da Silva (Universidade Federal Fluminense, Niterói/RJ, Brazil)
12:20 h The bioflavonoids rutin and rutin succinate protect mice from hemostatic disorders evoked by envenomation
Ana Teresa Azevedo Sachetto (Instituto Butantan, São Paulo/SP, Brazil)
12:35 h LUNCH
14:00 – 14:40 h PLENARY LECTURE V
Arms-races and the evolution of tetrodotoxin resistance
Edmond Brodie Jr (Utah State University, Utah, USA)
Chair: Taran Grant, USP, São Paulo, Brazil
14:40 – 16:10 h SESSION V
Amphibians’ defense: using the chemical arsenal against predators and microorganisms
Chairs: Marta M. Antoniazzi, Instituto Butantan, São Paulo, Brazil and Pedro L. M. Fontana, Instituto Butantan, São Paulo, Brazil
14:40 h The cutaneous glands in amphibians and their role in the adaptation to different environmental pressures
Carlos Jared (Instituto Butantan, São Paulo, Brazil
15:05 h Chemical Defense in Poison Frogs
Taran Grant (USP, São Paulo, Brazil)
15:30 h The amphibian skin secretion: beyond the antimicrobial peptides
Daniel Pimenta (Instituto Butantan, São Paulo, Brazil)
15:55: h Prospection of the antiviral effect of bufotenine on the rabies virus infection inhibition
Patricia Mariano Cruz Pereira (Instituto Butantan, São Paulo/SP, Brazil)
15:55 – 16:35 h PLENARY LECTURE VI
Venom components with insecticidal activity found in major animal phyla
Jan Tytgat (KU Leuven, Belgium)
Chair: Maria Elena de Lima Perez Garcia (Santa Casa BH Ensino e Pesquisa, Minas Gerais, Brazil)
16:35 – 18:05 h Discussion Panel II
Scorpions and Scorpionism: explanations and actions
Chairs: Fan Hui Wen, Instituto Butantan, São Paulo, Brazil and Yara Cury, Instituto Butantan, São Paulo, Brazil
16:35 h Climate change and poisonous species: the effect on the distribution and risk of accidents with species of the genus Tityus (Scorpiones,
Buthidae)
Pablo Ariel Martinez (Universidade Federal de Sergipe, Sergipe, Brazil)
16:50 h Why and how scorpions conquered cites
André Felipe Lira (Universidade Federal de Pernambuco, Pernambuco, Brazil)
17:05 h Clinical Aspects of Severe Scorpionism
Palmira Cupo (USP, Campus Ribeirão Preto, Ribeirão, Brazil)
17:20 h Why is so difficul to reduce the burden of escorpionism in Brazil?
Fan Hui Wen (Instituo Butantan, São Paulo, Brazil)
17:35 h Discussion
17:35 h – 18:00 h COFFE BREAK
17:35 h – 19:00 h
POSTER SESSION II
19:00 h – 20:00h
SBTx jovem activity ?Meet the Toxinologist?  

WEDNESDAY, May 29, 2019
8:00 h – 8:45 h COURSE
Strategies for valuing nature assets: the essential steps between the experimental findings and the drawing of business models
Ricardo A. Remer (Remer, Villaça & Nogueira, São Paulo, Brazil)
08:50 – 10:30 h Discussion Panel III
Future Perspectives for Toxinology and the SBTx
Moderator: Yara Cury (SBTx’s President)
9:00h Denise V. Tambourgi (Instituto Butantan, São Paulo, Brazil)
9:15h Jose Maria Gutierrez (Universidade da Costa Rica, San Jose, Costa Rica)
9:30h Benedito Barraviera (CEVAP, Botucatu, Brazil)
9:45h Next SBTx elected president
10:00h Discussion
10:30 – 11:30 h COFFE BREAK

SBTx jovem activitiy “Elevator Talk”

11:30 – 12:00 h CLOSING SESSION
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